Exploring Antibody Recognition of Sequence Space through Random-Sequence Peptide Microarrays
نویسندگان
چکیده
منابع مشابه
Exploring the sequence space of a DNA aptamer using microarrays
The relationship between sequence and binding properties of an aptamer for immunoglobulin E (IgE) was investigated using custom DNA microarrays. Single, double and some triple mutations of the aptamer sequence were created to evaluate the importance of specific base composition on aptamer binding. The majority of the positions in the aptamer sequence were found to be immutable, with changes at ...
متن کاملSeismic Data Forecasting: A Sequence Prediction or a Sequence Recognition Task
In this paper, we have tried to predict earthquake events in a cluster of seismic data on pacific ring of fire, using multivariate adaptive regression splines (MARS). The model is employed as either a predictor for a sequence prediction task, or a binary classifier for a sequence recognition problem, which could alternatively help to predict an event. Here, we explain that sequence prediction/r...
متن کاملExploring nitrilase sequence space for enantioselective catalysis.
Nitrilases are important in the biosphere as participants in synthesis and degradation pathways for naturally occurring, as well as xenobiotically derived, nitriles. Because of their inherent enantioselectivity, nitrilases are also attractive as mild, selective catalysts for setting chiral centers in fine chemical synthesis. Unfortunately, <20 nitrilases have been reported in the scientific and...
متن کاملEnvironmental Genomics: Exploring Ecological Sequence Space
The ability to extract and characterize genomic DNA fragments from mixed microbial assemblages is providing novel insights into the ecology, evolution, and metabolism of uncultured microorganisms in nature.
متن کاملA Voyage through Protein Sequence Space
The search for novel proteins is complicated by the diversity of amino acids, the non-linear relationship between amino acid sequence and folding and the huge size of sequence space. The goal of this research is to discover patterns in amino acid composition and sequence that relate to known or novel folds, thereby helping to constrain the search space for new functional proteins. This approach...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2011
ISSN: 1535-9476
DOI: 10.1074/mcp.m110.000786